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Attitudes about vaccines to prevent Ebola virus disease in Guinea at the end of a large Ebola epidemic: Results of a national household survey

4 Dec, 2017
KL Irwin, MF Jalloh, J Corker, BA Mahmoud, SJ Robinson, W Li, NE James, M Sellu, MB Jalloh, AA Dialloe, L Tracy, R Hajjeh, A VanSteelandt, R Bunnell, L Martel, PL Raghunathan, B Marston., Source: Vaccine

Introduction

In 2014–2016, an Ebola epidemic devastated Guinea; more than 3800 cases and 2500 deaths were reported to the World Health Organization. In August 2015, as the epidemic waned and clinical trials of an experimental, Ebola vaccine continued in Guinea and neighboring Sierra Leone, we conducted a national household survey about Ebola-related knowledge, attitudes, and practices (KAP) and opinions about “hypothetical” Ebola vaccines.

Methods

Using cluster-randomized sampling, we selected participants aged 15+ years old in Guinea’s 8 administrative regions, which had varied cumulative case counts. The questionnaire assessed socio-demographic characteristics, experiences during the epidemic, Ebola-related KAP, and Ebola vaccine attitudes. To assess the potential for Ebola vaccine introduction in Guinea, we examined the association between vaccine attitudes and participants’ characteristics using categorical and multivariable analyses.

Results

Of 6699 persons invited to participate, 94% responded to at least 1 Ebola vaccine question. Most agreed that vaccines were needed to fight the epidemic (85.8%) and that their family would accept safe, effective Ebola vaccines if they became available in Guinea (84.2%). These measures of interest and acceptability were significantly more common among participants who were male, wealthier, more educated, and lived with young children who had received routine vaccines. Interest and acceptability were also significantly higher among participants who understood Ebola transmission modes, had witnessed Ebola response teams, knew Ebola-affected persons, believed Ebola was not always fatal, and would access Ebola treatment centers. In multivariable analyses of the majority of participants living with young children, interest and acceptability were significantly higher among those living with vaccinated children than among those living with unvaccinated children.

Discussion

The high acceptability of hypothetical vaccines indicates strong potential for introducing Ebola vaccines across Guinea. Strategies to build public confidence in use of Ebola vaccines should highlight any similarities with safe, effective vaccines routinely used in Guinea.

This entry was posted on Monday, December 4th, 2017 at 9:18 am and is filed under Literature.

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Literature Literature archive

HC Maltezou, C Ledda, V Rapisarda 2019 Vaccine Vol 37(32): 4419-4658
Sabahelzain MM et al. 2019 PLoS ONE VOl 14 (6): e0213882.
KT Paul, K Loer 2019 Journal of Public Health Policy Volume 40, Issue 2
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The Vaccine Knowledge Project at the Oxford Vaccine Group